SCIENZE MEDICO-CHIRURGICHE E FARMACOLOGICHEModule FARMACOLOGIA GENERALE E FARMACOTOSSICOLOGIA
Academic Year 2023/2024 - Teacher: GIULIA DI BENEDETTOExpected Learning Outcomes
To transmit the main principles of pharmacokinetics and cellular and molecular pharmacology; to deepen the concepts of drug-receptor interaction and response.
Course Structure
Traditional classes.
If the teaching is given in a mixed or remote mode, necessary changes may be introduced in order to fulfill all statements in the Syllabus
Required Prerequisites
Basic knowledge in the
following topics: Anatomy, Biochemistry, Physiology and Pathology.
Attendance of Lessons
Mandatory
Detailed Course Content
- Routes of drug administration
- Drug absorption
- Drug distribution
- Drug metabolism
- Drug elimination
- PK parameters
- Drug-Receptor interactions
- Agonists and antagonists
- Signal transduction
- Desensitization and tachyphylaxis
- Sympathetic neurons, adrenergic agonists and antagonists
- Parasympathetic neurons, cholinergic agonists and antagonists
- Pharmacovigilance
- Therapeutic index, DE50, DT50
- Drug Development Phases
- Basic principles of carcinogensis, mutagenesis and teratogenesis
Textbook Information
Clementi F., Fumagalli G.: Farmacologia generale e molecolare - V edizione – EDRA 2018
Clark M.A. et al. - Le basi della farmacologia - Ed. Zanichelli.Course Planning
| Subjects | Text References | |
|---|---|---|
| 1 | Routes of drug administration | see text book tab |
| 2 | Drug absorption | see text book tab |
| 3 | Drug distribution | see text book tab |
| 4 | Drug metabolism | see text book tab |
| 5 | Drug elimination | see text book tab |
| 6 | PK parameters | see text book tab |
| 7 | Receptors classification and drug-receptor interactions | see text book tab |
| 8 | Agonists and antagonists | see text book tab |
| 9 | Signal transduction | see text book tab |
| 10 | Desensitization and tachyphylaxis | see text book tab |
| 11 | Cholinergic transmission | see text book tab |
| 12 | Adrenergic transmission | see text book tab |
| 13 | Pharmacovigilance | see text book tab |
| 14 | Therapeutic index | see text book tab |
| 15 | Drug Development Phases | see text book tab |
| 16 | Basic principles of carcinogensis, mutagenesis and teratogenesis | see text book tab |
Learning Assessment
Learning Assessment Procedures
Oral exam
Examples of frequently asked questions and / or exercises
Routes of drug administration; concentration-response curve, teratogenesis; adverse drug reactions.