SCIENZE CLINICHE

Learning Objectives

• Clinical Sciences - Medical Oncology

  Students will have to describe the main mechanisms underlying cancer pathogenesis and will have to define the appropriate procedures required for the diagnosis of the most common forms of cancer. Description of currently employed techniques and their usefulness in tumor diagnosis will also be required. Finally, students will have to acquire rudimental notions concerning both conventional chemotherapeutic drugs and novel anti-tumoral biological compounds.

• Blood Disorders

  The aim of the course is to allow the student to recognize the different hematological diseases with insights into methodology necessary to identify, classify and monitor: automated hematological methods, cytogenetics and molecular biology, flow cytometry, electrophoretic methods to measure specific analytes as markers of hematological malignancy.

• Blood disorders II

  The aim of the course is to allow the student to recognize the different hematological diseases with insights into the methodology necessary to identify, classify and monitor: automated hematological methods, cytogenetics and molecular biology, flow cytometry, electrophoretic methods to measure specific analytes as markers of hematological malignancy.

Course Structure

• Clinical Sciences - Medical Oncology

  Frontal Teaching and Interactive Discussion.

• Blood Disorders

  1. Structure of bone marrow and hematopoiesis

  2. Evaluation of blood count and peripheral blood smears

  3. Normocytic anemias (post hemorrhagic, caused by kidney disease or by maturation block)

  4. Microcytic anemias and thalassemias

  5. Macrocytic anemias (B12 and folate deficiency)

  6. Hemoglobinopathies and hemolytic anemias

  7. Pathophysiology of hemostasis

  8. Platelet pathologies and hemorrhagic syndromes

  9. Thrombosis

  10. Transfusion laboratory

• Blood disorders II

  Basic notions on Hematology as to be of use in future daily practice will be teached in lessons as reported on the academic calendar

Detailed Course Content

• Clinical Sciences - Medical Oncology

  Tumor Biology

  • Oncogenes, Tumor Suppressor Genes
  • Stochastic Cancerogenesis and Cancer Stem Cells
  • Angiogenesis, Tumor Heterogeneity and Metastasis

   

  Epidemiology and Cancer Prevention

  • Incidence, Prevalence and Mortality Rates in Oncology
  • Risk Factors for the Most Common Tumors
  • Primary, Secondary and Tertiary Prevention

   

  Clinical Methodology in Oncology

  • Tumor Classification and Staging
  • Cancer Biomarkers

   

  Principles of Cancer Therapy

  • Conventional Chemotherapeutic Drugs
  • Hormonal Therapy
  • Targeted Therapies in Oncology
• Blood Disorders

  n

• Blood disorders II
  1. Cytogenetics and molecular biology in hematological malignancies
  2. The role of immunophenotyping in the diagnosis of hematological malignancies and for minimal residual disease evaluation
  3. Acute Leukemias
  4. Chronic myeloid leukemia
  5. Chronic myeloproliferative neoplasms
  6. Myelodysplastic syndromes
  7. Hodgkin and non-Hodgkin Lymphomas
  8. Chronic lymphocytic leukemia
  9. Monoclonal Gammopathies and Multiple Myeloma
  10. Transplantation of autologous and allogeneic hematopoietic stem cells

Textbook Information

• Clinical Sciences - Medical Oncology
  1. C. B. Thompson, J. W. Gray, J. Mendelsohn, M. A. Israel, P. M. Howley - The Molecular Basis of Cancer - 2014 - Saunders
  2. Collegio degli Oncologi Medici Italiani - Manuale di Oncologia Medica - 2018 - Edizioni Minerva Medica
• Blood Disorders

  1. “Manuale di Malattie del Sangue” Alberto Bosi, Valerio De Stefano, Francesco Di Raimondo, Giorgio La Nasa- Elsevier

  2. “Ematologia Per medicina, scienze biologiche, biotecnologie mediche” di N. Giuliani, A. Olivieri - Idelson-Gnocchi

  3. “Manuale di ematologia”di Paolo Corradini, Robin Foà - Minerva Medica

  4. “Hematology. Pathophysiology, diagnosis and treatment” di Pier Luigi Zinzani, Sante Tura, Michele Cavo – Esculapio

• Blood disorders II

  1. “Manuale di Malattie del Sangue” Alberto Bosi, Valerio De Stefano, Francesco Di Raimondo, Giorgio La Nasa- Elsevier

  2. “Ematologia per Medicina, Scienze Biologiche, Biotecnologie Mediche” di N. Giuliani, A. Olivieri - Idelson-Gnocchi

  3. “Manuale di ematologia”di Paolo Corradini, Robin Foà - Minerva Medica

  4. “Hematology. Pathophysiology, diagnosis and treatment” di Pier Luigi Zinzani, Sante Tura, Michele Cavo – Esculapio